How to create a GenomicRanges object in Bioconductor using canonical transcripts
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<...Analyzing ICE Detention Data from 2021 to 2025
The ability to code and explore big datasets are generally useful skills that transfer well beyond our work of biomedical spatial omics analysis. In this blog post, I analyze publicly available datase...
Mastering Bioinformatics in the Age of AI: Foundational Skills for the Modern Scientist
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<...Could It Have Been Found With Short Reads?
Initially, the ESHG program was overwhelming. With the exception of the official opening and closing sessions, every timeslot had multiple parallel sessions - and sometimes those also had compet...
A recap of virtual cell releases circa June 2025
In October 2024, I twote that “something is deeply wrong” with what we now call virtual cell models. A lot has happened since then: modelers are advancing new architectures and mining new sources of i...
Food For Thought On ONT's Proteomics Push
This year, instead of touring London after the Nanopore confab I headed to Italy for the European Society of Human Genetics meeting. Upon hearing Lakmal Jayasinghe describe ONT's proteomics plan...
Five flavors of stratified LD score regression (Part 1, Vanilla)
Linkage disequilibrium score regression (LDSC) is a workhorse technique at the intersection of quantitative genetics and functional genomics. The core use of S-LDSC is to detect and quantify functiona...
Five flavors of stratified LD score regression (Part 2, Strawberry)
Stratified linkage disequilibrium score regression (S-LDSC) is a workhorse technique at the intersection of human genetics and functional genomics, but its exposition is heavily genetics-coded. In cel...
Five flavors of stratified LD score regression (Part 3, Cranberry)
Stratified linkage disequilibrium score regression (S-LDSC) is a workhorse technique at the intersection of human genetics and functional genomics, but its exposition is heavily genetics-coded. In cel...
Roche Gives SBX Updates - and a Name!
Last week I double-dipped on conferences, going from London Calling to European Society for Human Genetics (ESHG) in Milan. I have a raft of notes and ideas from these, which I'll try to spool out ov...