RNA velocity in situ infers gene expression dynamics using spatial transcriptomics data
Introduction...
How big would ABI377 plates need to be to deliver NovaSeq X Plus output?
<p>I asked ChatGPT this question one evening and working through the session was fun. Maybe it needs more fact-checking…I know some of my readers are fastidious enough to call me out if I’...
cfDNA fragmentomics reviewed
<p>This is a fantastic and comprehensive review on Cell-free DNA fragmentomics in cancer. Out in Cancer Cell by Denis Lo et al. In this review focused on cell-free DNA (cfDNA) fragmentomics ...
15th Anniversary
<p>It has been 15 years since I started this blog! As typical with many of my anniversary posts, I reflect on things that I have started to do and/or have learned since the last time I wrote an annive...
The case of the missing Editorial Blog Post (and journal team)
<p>Here’s a wee puzzle: A mature Open Data focused journal (“Journal A”), owned and launched by an company or Institute (“Institute B”), developed into the flagship of an Academic Publisher (“Publishe...
Unlocking the Potential of Urine-Based Liquid Biopsies
<p>I’m really pleased to say I’m an author on a new article in Nature Cancer discussing the potential of using urine-based liquid biopsies for cancer detection, particularly through the an...
Our journey through low-complexity regions
<p>Those who inspect SVs often have probably noticed many SVs fall in low-complexity regions (LCRs) or tandem repeats and they are challenging to call. How many and how challenging? I could not find a...
Back to Writing: Some Thoughts on Machine Learning
<p>Hello. Finally, I’m back to writing on the blog. Intense work commitments and plenty of unexpected events have limited the time I could spend studying and sharing with you my progress in the world ...
A quick look at Roche's SBX
<p><a href="https://sequencing.roche.com/us/en/article-listing/sequencing-platform-technologies.html">Sequencing by Expansion (SBX)</a> is Roche’s new short-read sequencing technology. Roche released ...
Job search 2025 post-mortem and advice
The comp bio job market is scarier than usual: 2023 was a biotech bankruptcy bloodbath, 2024 was a little better, and as far as layoffs, 2025 has been worse. Academic and government sectors are also r...