DEE2 database gets HDF5
<p>Here I’ll show you how to download and work with the new HDF5 datasets from DEE2 (dee2.io).</p><div class="section level2" id="introduction"><p style="margin: 0px 0px 10px;">HDF5 files are provide ...
Five flavors of stratified LD score regression (Part 1, Vanilla)
Linkage disequilibrium score regression (LDSC) is a workhorse technique at the intersection of quantitative genetics and functional genomics. The core use of S-LDSC is to detect and quantify functiona...
Reply to: Reply to: False positives in the study of memory-related gene expression
In the Nature paper “Spatial transcriptomics reveal neuron–astrocyte synergy in long-term memory” published on March 14th, 2024, authors Sun et al. claimed to identify cell-type specific t...
The Future of At-Home Oncology Testing: Tiny Drops, Big Insights?
<p>The journey for an oncology patient often involves a relentless cycle of clinic visits, treatments, and crucially to the work I am involved with, blood draws for diagnosis, monitoring and MRD. This...
Epistemic failure of epistemic failure
Earlier this year I came across this interesting post by mathematician Daniel Litt, where he pondered how many intrinsically true results in mathematics have been published with erroneous proofs: Does...
Dorado v1.0.0 and the v5.2.0 basecalling models
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2025 Molecular Ecology Prize goes to Rosemary Gillespie, for harnessing molecular phylogenetics to understand community assembly and ecology
The Molecular Ecology Prize Committee has announced the 2025 recipient of the award, which recognizes an outstanding scientist who has made significant contributions to the still-young field of molecu...
What have you done to your keyboard?! Hands Down Promethium on a MacBook
<p>There were a few stickers on the lid, but <i>why</i> does my laptop look like this now? In short, I'm learning to touchtype a non-qwerty layout.</p><p></p><table align="center" cellpadding="0" cell...
2025 Harry Smith Prize awarded to Óscar Romero-Báez for landscape genomics work that “sets a new standard”
The 2025 Harry Smith Prize, which recognizes the best paper published in Molecular Ecology or Molecular Ecology Resources in the previous year by an early career scholar, has been awarded to Óscar Rom...
Linear Regression Made Simple (and Sketchy!)
<p>Hi everyone! How are you doing? Today the sun is shining, and after some gym time and work, I finally found a moment to write a long article I’ve been wanting to share on my blog. You know, Andrew ...